RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia.

@article{Holland2011RAC2AA,
  title={RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia.},
  author={Mark Holland and Fernanda V Castro and Seema Alexander and Duncan L Smith and Jizhong Liu and Michael Walker and Danny A. Bitton and Kate Mulryan and Garry Ashton and Morgan G Blaylock and Steve Bagley and Yvonne Connolly and John Bridgeman and Crispin Miller and Shekhar Krishnan and Clare E Dempsey and Ashish Narayan Masurekar and Peter Stern and Anthony D. Whetton and Vaskar Saha},
  journal={Blood},
  year={2011},
  volume={118 3},
  pages={638-49}
}
We developed a murine model of CNS disease to obtain a better understanding of the pathogenesis of CNS involvement in pre-B-cell acute lymphoblastic leukemia (ALL). Semiquantitative proteomic discovery-based approaches identified unique expression of asparaginyl endopeptidase (AEP), intercellular adhesion molecule 1 (ICAM1), and ras-related C3 botulinum toxin substrate 2 (RAC2), among others, in an invasive pre-B-cell line that produced CNS leukemia in NOD-SCID mice. Targeting RAC2… CONTINUE READING
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