RAC1-dependent regulation of cholinergically induced lamellar protrusive activity is independent of MAPKinase and attenuated by active p-JNK.


In SH-SY5Y neuroblastoma cell bodies and growth cones the actin dynamics of cholinergically induced lamellar protrusion is demonstrated by live-imaging. Failure of this reaction in cells over-expressing a dominant negative RAC1-mutant (RAC1(T17N)) confirmed that the actin-dynamics of lamellar protrusion is also, in these cells, RAC1-dependent. Pretreatment… (More)


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