RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

  title={RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk},
  author={David A. MacLeod and Herve Rhinn and Tomoki Kuwahara and Ari Zolin and Gilbert Di Paolo and Brian D McCabe and Karen S. Marder and Lawrence S. Honig and Lorraine N. Clark and Scott A. Small and Asa Abeliovich},
Recent genome-wide association studies have linked common variants in the human genome to Parkinson's disease (PD) risk. Here we show that the consequences of variants at 2 such loci, PARK16 and LRRK2, are highly interrelated, both in terms of their broad impacts on human brain transcriptomes of unaffected carriers, and in terms of their associations with PD risk. Deficiency of the PARK16 locus gene RAB7L1 in primary rodent neurons, or of a RAB7L1 ortholog in Drosophila dopamine neurons… CONTINUE READING
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