RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway.

@article{AlonsoCurbelo2014RAB7CM,
  title={RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway.},
  author={Direna Alonso-Curbelo and Erica Riveiro-Falkenbach and Eva P{\'e}rez-Guijarro and Metehan Cifdaloz and Panagiotis Karras and Lisa Osterloh and Diego Meg{\'i}as and Estela Ca{\~n}{\'o}n and Tonantzin G. Calvo and David Olmeda and Gonzalo G{\'o}mez-L{\'o}pez and Osvaldo Gra{\~n}a and V{\'i}ctor Javier S{\'a}nchez-Ar{\'e}valo Lobo and David G. Pisano and Hao-Wei Wang and Pablo L Ortiz-Romero and Dami{\`a} Tormo and Keith S. Hoek and J L Rodr{\'i}guez-Peralto and Johanna A Joyce and Mar{\'i}a S Soengas},
  journal={Cancer cell},
  year={2014},
  volume={26 1},
  pages={
          61-76
        }
}
Although common cancer hallmarks are well established, lineage-restricted oncogenes remain less understood. Here, we report an inherent dependency of melanoma cells on the small GTPase RAB7, identified within a lysosomal gene cluster that distinguishes this malignancy from over 35 tumor types. Analyses in human cells, clinical specimens, and mouse models demonstrated that RAB7 is an early-induced melanoma driver whose levels can be tuned to favor tumor invasion, ultimately defining metastatic… CONTINUE READING

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