RAB43 facilitates cross-presentation of cell-associated antigens by CD8α+ dendritic cells

@inproceedings{Kretzer2016RAB43FC,
  title={RAB43 facilitates cross-presentation of cell-associated antigens by CD8α+ dendritic cells},
  author={Nicole M. Kretzer and Derek J Theisen and Roxane Tussiwand and Carlos G. Brise{\~n}o and Gary E. Grajales-Reyes and Xiaodi Wu and Vivek Durai and J{\"o}rn C. Albring and Prachi Bagadia and Theresa L. Murphy and Kenneth M Murphy},
  booktitle={The Journal of experimental medicine},
  year={2016}
}
In this study, to examine cross-presentation by classical dendritic cells (DCs; cDCs), we evaluated the role of RAB43, a protein found to be selectively expressed by Batf3-dependent CD8α+ and CD103+ compared with other DC subsets and immune lineages. Using a specific monoclonal antibody, we localized RAB43 expression to the Golgi apparatus and LAMP1- cytoplasmic vesicles. Mice with germline or conditional deletion of Rab43 are viable and fertile and have normal development of cDCs but show a… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 16 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…