RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway

@inproceedings{Zhang2012RAB62AT,
  title={RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway},
  author={Donglei Zhang and Nora R. Isack and Doreen R. Glodowski and Jie Liu and Carlos Chih-Hsiung Chen and Xu-Feng Xu and Barth D Grant and Christopher Rongo},
  booktitle={The Journal of cell biology},
  year={2012}
}
Regulated membrane trafficking of AMPA-type glutamate receptors (AMPARs) is a key mechanism underlying synaptic plasticity, yet the pathways used by AMPARs are not well understood. In this paper, we show that the AMPAR subunit GLR-1 in Caenorhabditis elegans utilizes the retrograde transport pathway to regulate AMPAR synaptic abundance. Mutants for rab-6.2, the retromer genes vps-35 and snx-1, and rme-8 failed to recycle GLR-1 receptors, resulting in GLR-1 turnover and behavioral defects… CONTINUE READING

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