RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans

@article{Sasidharan2012RAB5AR,
  title={RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans},
  author={N. Sasidharan and Marija Sumakovic and M. Hannemann and J. Hegermann and J. Liewald and C. Olendrowitz and S. Koenig and B. Grant and S. Rizzoli and A. Gottschalk and S. Eimer},
  journal={Proceedings of the National Academy of Sciences},
  year={2012},
  volume={109},
  pages={18944 - 18949}
}
Neurons secrete neuropeptides from dense core vesicles (DCVs) to modulate neuronal activity. Little is known about how neurons manage to differentially regulate the release of synaptic vesicles (SVs) and DCVs. To analyze this, we screened all Caenorhabditis elegans Rab GTPases and Tre2/Bub2/Cdc16 (TBC) domain containing GTPase-activating proteins (GAPs) for defects in DCV release from C. elegans motoneurons. rab-5 and rab-10 mutants show severe defects in DCV secretion, whereas SV exocytosis is… Expand
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