R5 human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in primary CD4+ T-cell cultures than X4 HIV-1.

@article{Schweighardt2004R5HI,
  title={R5 human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in primary CD4+ T-cell cultures than X4 HIV-1.},
  author={Becky Schweighardt and Ann-Marie Roy and Duncan A. Meiklejohn and Edward J. Grace and Walter J. Moretto and Jonas J Heymann and Douglas F Nixon},
  journal={Journal of virology},
  year={2004},
  volume={78 17},
  pages={9164-73}
}
In this report, we present evidence that R5 human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in primary CD4+ T cells than X4 HIV-1. By comparing CD3/CD28-costimulated CD4+ T-cell cultures infected by several X4 and R5 HIV-1 strains, we determined that R5-infected CD4+ T cells produce more virus over time than X4-infected CD4+ T cells. In the first comparison, we found that more cells were infected by the X4-tropic strain LAI than by the R5-tropic strain JR-CSF and yet… CONTINUE READING
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