R432 is a key residue for the multiple functions of Ndt80p in Candida albicans

@article{Yang2011R432IA,
  title={R432 is a key residue for the multiple functions of Ndt80p in Candida albicans},
  author={Yun Liang Yang and Chih Wei Wang and Shiang Ning Leaw and Te Pin Chang and I-Fan Wang and Chia Geun Chen and Jen Chung Fan and Kuo Yun Tseng and Szu Hsuan Huang and Chung Yung Chen and Ting Yin Hsiao and Chao A. Hsiung and Chiung Tong Chen and Chwan Deng Hsiao and Hsiu Jung Lo},
  journal={Cellular and Molecular Life Sciences},
  year={2011},
  volume={69},
  pages={1011-1023}
}
Ndt80p is an important transcription modulator to various stress-response genes in Candida albicans, the most common human fungal pathogen in systemic infections. We found that Ndt80p directly regulated its target genes, such as YHB1, via the mid-sporulation element (MSE). Furthermore, the ndt80R432A allele, with a reduced capability to bind MSE, failed to complement the defects caused by null mutations of NDT80. Thus, the R432 residue in the Ndt80p DNA-binding domain is involved in all tested… CONTINUE READING
BETA

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 27 REFERENCES