R213I mutation in release factor 2 (RF2) is one step forward for engineering an omnipotent release factor in bacteria Escherichia coli.

@article{Korkmaz2017R213IMI,
  title={R213I mutation in release factor 2 (RF2) is one step forward for engineering an omnipotent release factor in bacteria Escherichia coli.},
  author={G{\"u}rkan Korkmaz and Suparna Sanyal},
  journal={The Journal of biological chemistry},
  year={2017},
  volume={292 36},
  pages={15134-15142}
}
The current understanding of the specificity of the bacterial class I release factors (RFs) in decoding stop codons has evolved beyond a simple tripeptide anticodon model. A recent molecular dynamics study for deciphering the principles for specific stop codon recognition by RFs identified Arg-213 as a crucial residue on Escherichia coli RF2 for… CONTINUE READING