R-citalopram prevents the neuronal adaptive changes induced by escitalopram.

  title={R-citalopram prevents the neuronal adaptive changes induced by escitalopram.},
  author={Ouissame Mnie-Filali and C{\'e}line Faure and Mostafa El Mansari and Laura Lamb{\'a}s-Se{\~n}as and Anne B{\'e}rod and Luc Zimmer and Connie S{\'a}nchez and Nasser Haddjeri},
  volume={18 15},
This study examined the long-term effects of the antidepressant escitalopram on rat serotonin (5-HT) neuronal activity and hippocampal neuroplasticity. In the dorsal raphe nucleus, a 2-week treatment with escitalopram (10 mg/kg/day, subcutaneous) did not modify the firing activity of 5-HT neurons, whereas a cotreatment with R-citalopram (20 mg/kg/day, subcutaneous) decreased it. In the dentate gyrus of dorsal hippocampus, escitalopram increased significantly (57%) the number of de novo cells… CONTINUE READING
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