R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis.

@article{Kazanskaya2004RSpondin2IA,
  title={R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis.},
  author={Olga Kazanskaya and Andrei Glinka and Ivan del Barco Barrantes and Peter Stannek and Christof Niehrs and Wei Wu},
  journal={Developmental cell},
  year={2004},
  volume={7 4},
  pages={525-34}
}
We have carried out a small pool expression screen for modulators of the Wnt/beta-catenin pathway and identified Xenopus R-spondin2 (Rspo2) as a secreted activator of this cascade. Rspo2 is coexpressed with and positively regulated by Wnt signals and synergizes with Wnts to activate beta-catenin. Analyses of functional interaction with components of the Wnt/beta-catenin pathway suggest that Rspo2 functions extracellularly at the level of receptor ligand interaction. In addition to activating… CONTINUE READING
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