R-Spondin 1/Dickkopf-1/Beta-Catenin Machinery Is Involved in Testicular Embryonic Angiogenesis

  title={R-Spondin 1/Dickkopf-1/Beta-Catenin Machinery Is Involved in Testicular Embryonic Angiogenesis},
  author={Maria Giovanna Caruso and Francesca Ferranti and Katia Corano Scheri and Gabriella Dobrowolny and Fabio Ciccarone and Paola Grammatico and Angela Catizone and Giulia Ricci},
  booktitle={PloS one},
Testicular vasculogenesis is one of the key processes regulating male gonad morphogenesis. The knowledge of the molecular cues underlining this phenomenon is one of today's most challenging issues and could represent a major contribution toward a better understanding of the onset of testicular morphogenetic disorders. R-spondin 1 has been clearly established as a candidate for mammalian ovary determination. Conversely, very little information is available on the expression and role of R-spondin… CONTINUE READING
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