R-Ras is required for murine dendritic cell maturation and CD4+ T-cell priming.

@article{Singh2012RRasIR,
  title={R-Ras is required for murine dendritic cell maturation and CD4+ T-cell priming.},
  author={Gobind C. Singh and Daigo Hashimoto and Xiaocai Yan and Julie Helft and Patricia J-Y Park and Ge Ma and Rui Fang Qiao and Cristopher Kennedy and Shu-hsia Chen and Miriam Merad and Andrew M L Chan},
  journal={Blood},
  year={2012},
  volume={119 7},
  pages={
          1693-701
        }
}
R-Ras is a member of the RAS superfamily of small GTP-binding proteins. The physiologic function of R-Ras has not been fully elucidated. We found that R-Ras is expressed by lymphoid and nonlymphoid tissues and drastically up-regulated when bone marrow progenitors are induced to differentiate into dendritic cells (DCs). To address the role of R-Ras in DC functions, we generated a R-Ras-deficient mouse strain. We found that tumors induced in Rras(-/-) mice formed with shorter latency and attained… CONTINUE READING
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