R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.

@article{Guo2015RKetorolacTC,
  title={R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.},
  author={Yuna Guo and S. Ray Kenney and Carolyn Y. Muller and Sarah F. Adams and Teresa L. Rutledge and Elsa G Romero and Cristina Murray-Krezan and Rytis Prekeris and Larry A. Sklar and Laurie G. Hudson and Angela Wandinger-Ness},
  journal={Molecular cancer therapeutics},
  year={2015},
  volume={14 10},
  pages={2215-27}
}
Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum toxin substrate 1) are attractive therapeutic targets in ovarian cancer based on established importance in tumor cell migration, adhesion, and invasion. Despite a predicted benefit, targeting GTPases has not yet been translated to clinical practice. We previously established that Cdc42 and constitutively active Rac1b are overexpressed in primary ovarian tumor tissues. Through high-throughput screening and computational… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Rho GTPases

Methods in Molecular Biology • 2018
View 20 Excerpts
Highly Influenced

Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer

Journal of experimental & clinical cancer research : CR • 2017
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Selected NSAIDs targetGTPases forovarian cancer therapy. [abstract

Y Guo, SR Kenney, +3 authors C Muller
Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, • 2013
View 7 Excerpts
Highly Influenced

Rho GTPases in hepatocellular carcinoma.

Biochimica et biophysica acta • 2009
View 10 Excerpts
Highly Influenced

Rho GTPases: masters of cell migration.

Small GTPases • 2014
View 3 Excerpts
Highly Influenced

Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat.

The Journal of pharmacology and experimental therapeutics • 1999
View 4 Excerpts
Highly Influenced

A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2015
View 5 Excerpts

A pilot trial to study the availability and effect of post-OP IV ketorolac on ovarian, fallopian tube or primary peritoneal cancer, cells retrieved from the peritoneal cavity [cited

C. Muller
2015

Similar Papers

Loading similar papers…