R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.

  title={R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.},
  author={Yuna Guo and S. Ray Kenney and Carolyn Y. Muller and Sarah F. Adams and Teresa L. Rutledge and Elsa G Romero and Cristina Murray-Krezan and Rytis Prekeris and Larry A. Sklar and Laurie G. Hudson and Angela Wandinger-Ness},
  journal={Molecular cancer therapeutics},
  volume={14 10},
Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum toxin substrate 1) are attractive therapeutic targets in ovarian cancer based on established importance in tumor cell migration, adhesion, and invasion. Despite a predicted benefit, targeting GTPases has not yet been translated to clinical practice. We previously established that Cdc42 and constitutively active Rac1b are overexpressed in primary ovarian tumor tissues. Through high-throughput screening and computational… CONTINUE READING


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