R-Isovaline: a subtype-specific agonist at GABA(B)-receptors?

  title={R-Isovaline: a subtype-specific agonist at GABA(B)-receptors?},
  author={James E Cooke and David A Mathers and Ernest Puil},
The R-enantiomer of isovaline, an analgesic amino acid, has a chemical structure similar to glycine and GABA. Although its actions on thalamic neurons are strychnine-resistant and independent of the Cl(-) gradient, R-isovaline increases membrane conductance for K(+). The purpose of this study was to determine if R-isovaline activated metabotropic GABA(B) receptors. We used whole-cell voltage-clamp recordings to characterize the effects of R-isovaline applied by bath perfusion and local ejection… CONTINUE READING