R-Flurbiprofen Reduces Neuropathic Pain in Rodents by Restoring Endogenous Cannabinoids

  title={R-Flurbiprofen Reduces Neuropathic Pain in Rodents by Restoring Endogenous Cannabinoids},
  author={Philipp Bishay and Helmut Schmidt and Claudiu Marian and Annett H{\"a}ussler and Nina Wijnvoord and Simone Ziebell and Julia Metzner and Marco Koch and Thekla Myrczek and Ingo Bechmann and Rohini Kuner and Michael Costigan and Faramarz Dehghani and Gerd Geisslinger and Irmgard Tegeder},
  journal={PLoS ONE},
Background R-flurbiprofen, one of the enantiomers of flurbiprofen racemate, is inactive with respect to cyclooxygenase inhibition, but shows analgesic properties without relevant toxicity. Its mode of action is still unclear. Methodology/Principal Findings We show that R-flurbiprofen reduces glutamate release in the dorsal horn of the spinal cord evoked by sciatic nerve injury and thereby alleviates pain in sciatic nerve injury models of neuropathic pain in rats and mice. This is mediated by… 

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