R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine

@article{Zhang2014RS,
  title={R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine},
  author={Ji-chun Zhang and Su-xia Li and K. Hashimoto},
  journal={Pharmacology Biochemistry and Behavior},
  year={2014},
  volume={116},
  pages={137-141}
}
The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine is one of the most attractive antidepressants for treatment-resistant major depressive disorder (MDD). Ketamine (or RS (±)-ketamine) is a racemic mixture containing equal parts of R (-)-ketamine and S (+)-ketamine. In this study, we examined the effects of R- and S-ketamine on depression-like behavior in juvenile mice after neonatal dexamethasone (DEX) exposure. In the tail suspension test (TST) and forced swimming test (FST), both… Expand
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