R(+)-Methanandamide-Induced Apoptosis of Human Cervical Carcinoma Cells Involves A Cyclooxygenase-2-Dependent Pathway

@article{Eichele2008RMethanandamideInducedAO,
  title={R(+)-Methanandamide-Induced Apoptosis of Human Cervical Carcinoma Cells Involves A Cyclooxygenase-2-Dependent Pathway},
  author={K. Eichele and R. Ramer and B. Hinz},
  journal={Pharmaceutical Research},
  year={2008},
  volume={26},
  pages={346-355}
}
PurposeCannabinoids have received renewed interest due to their antitumorigenic effects. Using human cervical carcinoma cells (HeLa), this study investigates the role of cyclooxygenase-2 (COX-2) in apoptosis elicited by the endocannabinoid analog R(+)-methanandamide (MA).MethodsCOX-2 expression was assessed by RT-PCR and Western blotting. PGE2/PGD2 levels in cell culture supernatants and DNA fragmentation were measured by ELISA.ResultsMA led to an induction of COX-2 expression, PGD2 and PGE2… Expand
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