R/G-band boundaries: genomic instability and human disease.

  title={R/G-band boundaries: genomic instability and human disease.},
  author={Yoshihisa Watanabe and Masato Maekawa},
  journal={Clinica chimica acta; international journal of clinical chemistry},
The human genome is composed of large-scale compartmentalized structures resulting from variations in the amount of guanine and cytosine residues (GC%) and in the timing of DNA replication. These compartmentalized structures are related to the light- and dark-staining bands along chromosomes after the appropriate staining. Here we describe our current understanding of the biological importance of the boundaries between these light and dark bands (the so-called R/G boundaries). These R/G… CONTINUE READING