Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms

@article{Singh2000QuorumsensingSI,
  title={Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms},
  author={Pradeep K. Singh and Amy L. Schaefer and Matthew R. Parsek and Thomas O. Moninger and Michael J. Welsh and E. Peter Greenberg},
  journal={Nature},
  year={2000},
  volume={407},
  pages={762-764}
}
The bacterium Pseudomonas aeruginosa permanently colonizes cystic fibrosis lungs despite aggressive antibiotic treatment. This suggests that P. aeruginosa might exist as biofilms—structured communities of bacteria encased in a self-produced polymeric matrix—in the cystic fibrosis lung. Consistent with this hypothesis, microscopy of cystic fibrosis sputum shows that P. aeruginosa are in biofilm-like structures. P. aeruginosa uses extracellular quorum-sensing signals (extracellular chemical… 
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