Quorum-sensing-negative (lasR) mutants of Pseudomonas aeruginosa avoid cell lysis and death.

@article{Heurlier2005QuorumsensingnegativeM,
  title={Quorum-sensing-negative (lasR) mutants of Pseudomonas aeruginosa avoid cell lysis and death.},
  author={Karin Heurlier and Val{\'e}rie D{\'e}nervaud and Marisa Haenni and Lionel Guy and Viji Krishnapillai and Dieter Haas},
  journal={Journal of bacteriology},
  year={2005},
  volume={187 14},
  pages={
          4875-83
        }
}
In Pseudomonas aeruginosa, N-acylhomoserine lactone signals regulate the expression of several hundreds of genes, via the transcriptional regulator LasR and, in part, also via the subordinate regulator RhlR. This regulatory network termed quorum sensing contributes to the virulence of P. aeruginosa as a pathogen. The fact that two supposed PAO1 wild-type strains from strain collections were found to be defective for LasR function because of independent point mutations in the lasR gene led to… CONTINUE READING

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