Quorum sensing-mediated regulation of staphylococcal virulence and antibiotic resistance.

Abstract

Accessory gene regulator (agr)-mediated quorum sensing plays a central role in staphylococcal pathogenesis. It primarily upregulates secreted virulence factors and downregulates cell surface proteins, thereby governing invasiveness of staphylococci and cell dispersal from biofilms. Except for α- and β-PSMs, which are directly controlled by AgrA, the… (More)
DOI: 10.2217/fmb.14.31

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