Quorum sensing inhibitory potential and molecular docking studies of sesquiterpene lactones from Vernonia blumeoides.

  title={Quorum sensing inhibitory potential and molecular docking studies of sesquiterpene lactones from Vernonia blumeoides.},
  author={A. Aliyu and N. Koorbanally and B. Moodley and P. Singh and H. Chenia},
  • A. Aliyu, N. Koorbanally, +2 authors H. Chenia
  • Published 2016
  • Biology, Medicine
  • Phytochemistry
  • The increasing incidence of multidrug-resistant Gram-negative bacterial pathogens has focused research on the suppression of bacterial virulence via quorum sensing inhibition strategies, rather than the conventional antimicrobial approach. The anti-virulence potential of eudesmanolide sesquiterpene lactones previously isolated from Vernonia blumeoides was assessed by inhibition of quorum sensing and in silico molecular docking. Inhibition of quorum sensing-controlled violacein production in… CONTINUE READING
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