Quorum-sensing inhibitors as anti-pathogenic drugs.

  title={Quorum-sensing inhibitors as anti-pathogenic drugs.},
  author={Thomas Bovbjerg Rasmussen and Michael C Givskov},
  journal={International journal of medical microbiology : IJMM},
  volume={296 2-3},
Quorum-sensing (QS) signalling systems of pathogens are central regulators for the expression of virulence factors and represent highly attractive targets for the development of novel therapeutics. In Pseudomonas aeruginosa, QS systems are also involved in elevated antibiotic tolerance of biofilms as well as elevated tolerance to the activity of the innate immune system. Gram-negative bacteria commonly use N-acyl homoserine lactones (AHL) as QS signal molecules. The use of signal molecule based… CONTINUE READING
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