Quorum sensing inhibitors: a patent overview

@article{Pan2009QuorumSI,
  title={Quorum sensing inhibitors: a patent overview},
  author={Jiachuan Pan and Dacheng Ren},
  journal={Expert Opinion on Therapeutic Patents},
  year={2009},
  volume={19},
  pages={1581 - 1601}
}
Background: Quorum sensing (QS) is a microbial cell–cell signaling system that correlates gene expression with cell population density. It plays important roles in intra-species communications and is also involved in inter-species and microbe-host interactions. Because QS controls a wide spectrum of phenotypes including virulence and biofilm formation, inhibition of QS may provide alternative therapeutic methods for treating microbial infections. Objective: To provide an overview of QS… Expand
Quorum sensing inhibitors: a patent review (2014–2018)
TLDR
QS inhibition can reduce the virulence of bacteria without affecting their growth or killing them and the reduced pressure may minimize the increasingly resistance. Expand
Modulation of Bacterial Quorum Sensing by Eukaryotes
TLDR
Key mechanisms adapted by eukaryotes such as algae, fungi, plants, and animals both to sense bacterial quorum sensing signals and to employ bacterial QS modulators to regulate interkingdom interactions such as symbiosis, altered biofilm production, pathogenesis, etc. Expand
Interference in Bacterial Quorum Sensing: A Biopharmaceutical Perspective
TLDR
The efficacy of QSIs and QQ enzymes has been demonstrated in various animal models and are now considered in the development of new medical devices against bacterial infections, including dressings, and catheters for enlarging the therapeutic arsenal against bacteria. Expand
Fungal Quorum Sensing Inhibitors
TLDR
Fungal QSIs have been successfully tested under laboratory conditions to inhibit bacteria from forming biofilms on medical equipment and reduce spoilage of processed food products, and are also a promising agent to counter increasing antibiotic-resistance amongst bacteria. Expand
Attenuating Staphylococcus aureus Virulence Gene Regulation: A Medicinal Chemistry Perspective
TLDR
In this Perspective, insights into medicinal chemistry strategies for the development of chemical reagents that have the capacity to inhibit staphylococcal virulence expression are provided. Expand
Quorum Sensing Inhibition by Marine Bacteria
TLDR
Mechanisms of bacterial communication involved in biofilm formation are described and the potential of marine bacteria and their bioactive components as QS inhibitors is provided. Expand
Novel approaches for the design and discovery of quorum-sensing inhibitors
TLDR
The authors provide an overview of the literature, including research papers, mostly dealing with inhibitors of the Staphylococcus aureus and Pseudomonas aeruginosa QS systems, and reviews dealing with the application of the newest technologies in the field. Expand
Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators.
TLDR
Evaluated triazole-containing analogs of natural N-acyl L-homoserine lactone (AHL) signals as non-native QS agonists and antagonists in Gram-negative bacteria identified that were capable of strongly modulating the activity of LasR and AbaR. Expand
Evolution of Resistance to Quorum Quenching in Digital Organisms
TLDR
The results show that digital organisms can serve as a model to study the evolution and disruption of QS, potentially informing wet-lab studies aimed at identifying targets for anti-infective development. Expand
The LuxS/AI-2 system of Streptococcus suis
TLDR
Evidence has been brought that LuxS/AI-2 system controls major virulence determinants in Streptococcus suis and, as such, the ability of this bacterial species to cause infections in humans and pigs is controlled. Expand
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References

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TLDR
QS contributes to environmental adaptation by facilitating the elaboration of virulence determinants in pathogenic species and plant biocontrol characteristics in beneficial species as well as directing biofilm formation and colony escape and crosses the prokaryotic-eukaryotic boundary in that QS signal molecules influence the behaviour of eukaryotes in both the plant and mammalian worlds. Expand
Screening for Quorum-Sensing Inhibitors (QSI) by Use of a Novel Genetic System, the QSI Selector
TLDR
GeneChip-based transcriptome analysis revealed that garlic extract and 4-NPO had specificity for QS-controlled virulence genes in Pseudomonas aeruginosa, and these two QSIs significantly reduced P. aerug inosa biofilm tolerance to tobramycin treatment as well as virulence in a Caenorhabditis elegans pathogenesis model. Expand
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TLDR
An immunopharmacotherapeutic approach for the attenuation of QS in the Gram-positive human pathogen Staphylococcus aureus is reported, providing a strong foundation for further investigations of Immunopharmacotherapy for the treatment of bacterial infections in which QS controls the expression of virulence factors. Expand
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TLDR
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TLDR
Because many pathogens require quorum sensing to produce virulence factors in response to association with a human host, the signaling pathway is a target for design of small-molecule inhibitors. Expand
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TLDR
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TLDR
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TLDR
Variations in the design of the extracellular signals, the signal detection apparatuses, and the biochemical mechanisms of signal relay have allowed quorum sensing systems to be exquisitely adapted for their varied uses. Expand
Interference with AI-2-mediated bacterial cell–cell communication
TLDR
It is shown that some species of bacteria can manipulate AI-2 signalling and interfere with other species' ability to assess and respond correctly to changes in cell population density. Expand
Synthesis and Evaluation of New Antagonists of Bacterial Quorum Sensing in Vibrio harveyi
TLDR
Based on the structures of two lead inhibitors against autoinducer‐2‐mediated quorum sensing identified through virtual screening, 39 analogues were synthesized and showed equal or better inhibitory activities than the lead inhibitors. Expand
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