Quorum sensing in Pseudomonas aeruginosa controls expression of catalase and superoxide dismutase genes and mediates biofilm susceptibility to hydrogen peroxide.

@article{Hassett1999QuorumSI,
  title={Quorum sensing in Pseudomonas aeruginosa controls expression of catalase and superoxide dismutase genes and mediates biofilm susceptibility to hydrogen peroxide.},
  author={Daniel J Hassett and Jianmxin Ma and James G. Elkins and Timothy R McDermott and Urs A Ochsner and Susan E. H. West and Cheng Ting Huang and Janine Fredericks and Stephanie Burnett and Philip S Stewart and GA McFeters and Luciano Passador and Barbara H. Iglewski},
  journal={Molecular microbiology},
  year={1999},
  volume={34 5},
  pages={1082-93}
}
Quorum sensing (QS) governs the production of virulence factors and the architecture and sodium dodecyl sulphate (SDS) resistance of biofilm-grown Pseudomonas aeruginosa. P. aeruginosa QS requires two transcriptional activator proteins known as LasR and RhlR and their cognate autoinducers PAI-1 (N-(3-oxododecanoyl)-L-homoserine lactone) and PAI-2 (N-butyryl-L-homoserine lactone) respectively. This study provides evidence of QS control of genes essential for relieving oxidative stress. Mutants… CONTINUE READING
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