Quorum quenching quandary: resistance to antivirulence compounds

@article{Maeda2012QuorumQQ,
  title={Quorum quenching quandary: resistance to antivirulence compounds},
  author={Toshinari Maeda and Rodolfo Garc{\'i}a-Contreras and Mingming Pu and Lili Sheng and Luis Ren{\'e} Garc{\'i}a and Mar{\'i}a Jes{\'u}s Tom{\'a}s and Thomas K. Wood},
  journal={The ISME Journal},
  year={2012},
  volume={6},
  pages={493-501}
}
Quorum sensing (QS) is the regulation of gene expression in response to the concentration of small signal molecules, and its inactivation has been suggested to have great potential to attenuate microbial virulence. It is assumed that unlike antimicrobials, inhibition of QS should cause less Darwinian selection pressure for bacterial resistance. Using the opportunistic pathogen Pseudomonas aeruginosa, we demonstrate here that bacterial resistance arises rapidly to the best-characterized compound… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 76 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa.

American journal of physiology. Gastrointestinal and liver physiology • 2007
View 8 Excerpts
Highly Influenced

An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants.

Proceedings of the National Academy of Sciences of the United States of America • 2006
View 4 Excerpts
Highly Influenced

Anti-virulence strategies to combat bacteria-mediated disease

Nature Reviews Drug Discovery • 2010
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…