Quorum quenching quandary: resistance to antivirulence compounds

  title={Quorum quenching quandary: resistance to antivirulence compounds},
  author={Toshinari Maeda and Rodolfo Garc{\'i}a-Contreras and Mingming Pu and Lili Sheng and Luis Ren{\'e} Garc{\'i}a and Mar{\'i}a Jes{\'u}s Tom{\'a}s and Thomas K. Wood},
  journal={The ISME Journal},
Quorum sensing (QS) is the regulation of gene expression in response to the concentration of small signal molecules, and its inactivation has been suggested to have great potential to attenuate microbial virulence. It is assumed that unlike antimicrobials, inhibition of QS should cause less Darwinian selection pressure for bacterial resistance. Using the opportunistic pathogen Pseudomonas aeruginosa, we demonstrate here that bacterial resistance arises rapidly to the best-characterized compound… CONTINUE READING
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