author={Harriet M. Lamb and David P. Figgitt and Diana M Faulds},
AbstractQuimipristin/dalfopristin is the first parenteral streptogramin antibacterial agent, and is a 30: 70 (w/w) ratio of 2 semisynthetic pristinamycin derivatives. The combination has inhibitory activity against a broad range of Gram-positive bacteria including methicillin-resistant staphylococci, vancomycin-resistant Enterococcus faecium (VREF), drug-resistant Streptococcus pneumoniae, other streptococci, Clostridium perfringens and Peptostreptococcus spp. The combination also has good… 

Streptogramins for the treatment of infections caused by Gram-positive pathogens

Despite its effectiveness in the treatment of severe Gram-positive bacterial infections demonstrated in several studies and the low rate of reported resistance, the clinical use of quinupristin-dalfopristin has remained limited, mainly due to its poor tolerance.

The recent evolution of therapeutic weapons

  • Medicine, Biology
  • 2015
The main problems related to the epidemiology of multiresistant gram-positive infection, the potential clinical indications of all recently available compounds compared with the standard of care of treatment of resistant Gram-positive infections, and updated data on efficacy and tolerability of all these compounds are updated and outlined on the ground of a review of recent literature evidences.

Enterococcal Endocarditis: Can We Win the War?

The best treatment of IE MDR enterococcal endocarditis is unknown and the paucity of antibiotics with bactericidal activity against these organisms is a cause of serious concern.

Synercid plus vancomycin for the Treatment of Severe Methicillin-resistant Staphylococcus aureus and Coagulase-negative Staphylococci Infections: Evaluation of 5 Cases

The experience with the combination of Synercid and vancomycin in 5 patients with severe infection caused by MRSA or methicillin-resistant coagulase-negative Staphylococcus is reported.

Prevalence and Antimicrobial Resistance of Enterococcus Species: A Hospital-Based Study in China

  • Wei JiaGang LiWen Wang
  • Biology, Medicine
    International journal of environmental research and public health
  • 2014
The monitoring of the prevalence and antimicrobial resistance of Enterococcus species is of great significance to guide the control and prevention of enterococcal infections.

Distribution of vancomycin resistant enterococci and their resistance patterns determined by surveillance

VRE strains had high levels of Ampicillin, Penicillin, Erythromycin, Rifampicin, Chloramphenicol and Nitrofurantoin resistance, while Quinolon resistance was found to be at moderate level, while Tetracycline and Linezolid were the most effective antimicrobials.

Gram-Positive Cocci Infections in Intensive Care

Therapeutic proposals have been modified according to the emergence of multiresistant cocci and adapted to epidemiological markers of individual infectious processes, geographical variations of these markers, the availability of new antibacterials, and advances in the knowledge of pharmacokinetic and pharmacodynamic aspects of their use.

Intravenous Antibiotics Used in the Treatment of Methicillin-Resistant Staphylococcus Aureus.

  • K. Scordo
  • Medicine, Biology
    AACN advanced critical care
  • 2015
Current intravenous antibiotics that are available for the empiric treatment of MRSA infections along with a newer phenomenon known as the "seesaw effect" are discussed.

Susceptibility of bacteria of the Enterococcus genus isolated on Lithuanian poultry farms

There was no significant correlation found between resistances of different species to different antimicrobial agents in vitro.