Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors.

  title={Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors.},
  author={Li Zhang and Beiying Qiu and Bin Xiong and Xin Li and Jingya Li and Xin Wang and Jia Li and Jingkang Shen},
  journal={Bioorganic & medicinal chemistry letters},
  volume={17 8},
A series of quinoxalinylurea-based inhibitors are synthesized and shown to be the novel and potent inhibitors against Jnk Stimulatory Phosphatase-1 (JSP-1), which is a special member of dual-specificity protein phosphatase (DSP) family. Biological assay and computational modeling studies showed the compounds were reversible and noncompetitive inhibitors of JSP-1. JSP-1 inhibitors may be useful for the treatment of inflammatory, vascular, neurodegenerative, metabolic, and oncological diseases in… CONTINUE READING