Quinoxaline derivatives are high-affinity antagonists of the NMDA receptor-associated glycine sites

@article{Kessler1989QuinoxalineDA,
  title={Quinoxaline derivatives are high-affinity antagonists of the NMDA receptor-associated glycine sites},
  author={Markus Kessler and Michel Baudry and Gary Lynch},
  journal={Brain Research},
  year={1989},
  volume={489},
  pages={377-382}
}
Membranes from rat telencephalon contain strychnine-insensitive glycine binding sites associated with NMDA receptors. Three quinoxaline derivatives, among them the high-affinity AMPA receptor antagonists CNQX and DNQX, were found to inhibit [3H]glycine binding to these sites with micromolar affinities. Binding of these compounds to the glycine site also inhibited glutamate-stimulated association and dissociation of [3H]TCP. This suggests that these AMPA antagonists, like the structurally… CONTINUE READING

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