Quinoxaline derivatives: structure-activity relationships and physiological implications of inhibition of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor-mediated currents and synaptic potentials.

@article{Randle1992QuinoxalineDS,
  title={Quinoxaline derivatives: structure-activity relationships and physiological implications of inhibition of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor-mediated currents and synaptic potentials.},
  author={John C. R. Randle and T Guet and C Bobichon and Christophe J. Moreau and P Curutchet and Bertrand Lambolez and Lia Prado de Carvalho and Alex A. Cordi and Jean Lepagnol},
  journal={Molecular pharmacology},
  year={1992},
  volume={41 2},
  pages={337-45}
}
The inhibitory potencies at excitatory amino acid (EAA) receptors of 11 quinoxaline derivatives were evaluated in two-electrode voltage-clamp recordings of Xenopus oocytes injected with rat cortex mRNA. Currents activated by kainate or (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) in Xenopus oocytes were inhibited competitively by all the quinoxaline derivatives, with apparent Ki values ranging from 0.27 to 300 microM against kainate and from 0.25 to 137 microM against… CONTINUE READING