Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1*

@article{Kher2014QuinoxalineBasedIO,
  title={Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1*},
  author={S. Kher and Maria Penzo and Simone Fulle and Jean-Paul Ebejer and P. Finn and M. Blackman and A. Jirgensons},
  journal={Chemistry of Heterocyclic Compounds},
  year={2014},
  volume={50},
  pages={1457-1463}
}
  • S. Kher, Maria Penzo, +4 authors A. Jirgensons
  • Published 2014
  • Chemistry
  • Chemistry of Heterocyclic Compounds
  • 2,3-Bis(phenylamino)quinoxalines have been identified as a novel class of malarial protease PfSUB1 inhibitors by screening of Malaria Box compounds. The synthesis of analog series and investigation of their inhibitory activity provided preliminary structure–activity relationship to create in silico models for binding of these compounds into the active site of PfSUB1. 
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