Quinoxalin-2(1H)-one derived AMPA-receptor antagonists: Design, synthesis, molecular docking and anticonvulsant activity


A new series of 4-acetyl-1-substituted-3,4-dihydroquinoxalin-2(1H)-ones (3–14) were designed and synthesized in order to evaluate their α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-receptor antagonism as a proposed mode of their anticonvulsant activity. The structure of the synthesized compounds was confirmed by elemental analysis and… (More)
DOI: 10.1007/s00044-017-1996-5


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