Quinopeptide formation associated with the disruptive effect of epigallocatechin-gallate on lysozyme fibrils.

@article{Cao2015QuinopeptideFA,
  title={Quinopeptide formation associated with the disruptive effect of epigallocatechin-gallate on lysozyme fibrils.},
  author={Na Nora Cao and Yujie Zhang and Shuang Feng and Cheng-Ming Zeng},
  journal={International journal of biological macromolecules},
  year={2015},
  volume={78},
  pages={
          389-95
        }
}
Numerous studies demonstrate that natural polyphenols can inhibit amyloid formation and disrupt preformed amyloid fibrils. In the present study, the fibril-disruptive effects of epigallocatechin-3-gallate (EGCG) were examined using lysozyme as a model protein. The results indicated that EGCG dose dependently inhibited lysozyme fibrillation and modified the peptide chains with quinonoid moieties under acidic conditions, as measured by ThT fluorescence, transmission electron microscopy, and an… CONTINUE READING
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