Quinones and quinols as inhibitors of lipid peroxidation

  title={Quinones and quinols as inhibitors of lipid peroxidation},
  author={Alan Mellors and Al. L. Tappel},
The influence of biological quinonoid compounds upon oxidative polymerization of lipids has been compared with that of simple quinones and antioxidants. A new procedure for the accelerated production and measurement of oxidative polymerization was used for this comparison. The biological quinones were found to be relatively ineffective as retarders of oxidative polymerization. Heme-catalyzed lipid peroxidation, as measured by oxygen uptake, was inhibited by ubiquinone and ubiquinol, both having… 
Ubiquinol: an endogenous antioxidant in aerobic organisms
Ubiquinol is the only known lipid-soluble antioxidant that animal cells can synthesize de novo, and for which there exist enzymic mechanisms that can regenerate the antioxidant from its oxidized form resulting from its inhibitory effect of lipid peroxidation.
Coenzyme Q and vitamin E need each other as antioxidants
This work describes and support a potential kinetic mechanism whereby vitamin E and coenzyme Q interact in such a way as to usurp the prooxidant effects of O2−.. physical interactions of vitamin Eand coen enzyme Q within the environment of the membrane lipid bilayer facilitate the recycling of vitaminE by ubisemiquinone and ubiquinol.
Dioxygen reduction, reduced oxygen species, oxygen toxicity and antioxidants — A commentary.
  • T. Ramasarma
  • Biology
    Indian journal of experimental biology
  • 2016
This commentary is a reappraisal of formation and reactivity of ROS in different cells, the active cellular oxidant forms, products of oxidant action on proteins, nucleic acids and lipids as marker of oxidants injury, bulk antioxidants of endogenous and exogenous origin, limited absorption occurrence and functions of polyphenolic classes.
Nourishing and health benefits of coenzyme Q10 - a review
The distribution and contents of two ubiquinones in foods, especially in several kinds of grapes, the benefits of CoQ 10 as nutritional and topical supplements and its therapeutic applications in various diseases are shown.
CoQ10’s cellular bioenergetic activity and antioxidant properties, and its functions for common clinical conditions such as cardiovascular and neurodegenerative diseases, cancer, diabetes, and renal failure are explored in this examination.
Effect of ubiquinol-10 on citral stability and off-flavor formation in oil-in-water (O/W) nanoemulsions.
Investigation of the effects of different concentrations of ubiquinol-10 (Q10H2) on citral's stability and off-flavor generation suggested that a low concentration of Q 10H2 may induce the majority of the ubisemiquinone (Q 10(•-))/ubiquin one (Q9) redox transition, which possibly endowed Q10H1 with pro-oxidant properties.
Antioxidant Action of Mobile Electron Carriers of the Respiratory Chain
The hypothesis that aerobic metabolism arose several times in evolution after oxygenic photosynthesis is not sustained by the above mentioned data, but the widespread use of molecular oxygen as final acceptor of electrons resulting from the oxidation of biological fuels was an evolutionary acquisition subsequent to the oxygen photosynthesis.
Coenzyme Q10 Supplementation Modulates NFκB and Nrf2 Pathways in Exercise Training.
Using of coenzyme Q10 can significantly elevate IκB, Nrf2 and HO-1 and reduce NFκB during exercise training, indicating an anti-inflammatory effect of Q10 and emphasizes its role in antioxidant defense.
The bioenergetics and free radical chemistry of CoQ10 are reviewed in Gian Paolo Littarru's book, Energy and Defense, published in 1994(1).
Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome.


Uses of Isotopes in Addition Polymerization
A review is presented on advances in the knowledge of addition polymerization of unsaturated monomers that have resulted from the use of isotopes. The use of isotopes as tracers and the mechanistic