Quinone reductase inhibitors block SAPK/JNK and NFkappaB pathways and potentiate apoptosis.

  title={Quinone reductase inhibitors block SAPK/JNK and NFkappaB pathways and potentiate apoptosis.},
  author={Janet V Cross and Joseph C. Deak and Elizabeth A. Rich and Youcun Qian and Matthew C Lewis and Lou Parrott and Keiji Mochida and Daniel L. Gustafson and Scott B Vande Pol and Dennis J. Templeton},
  journal={The Journal of biological chemistry},
  volume={274 44},
A variety of environmental stresses stimulate the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEKK) > stress-activated protein kinase (SAPK)-ERK kinase (SEK) > SAPK/c-Jun NH(2)-terminal kinase (JNK) stress-activated protein kinase cascade and coordinately activate the transcription factor NFkappaB. Mechanisms of stress activation upstream of MEKK1 have not been precisely determined. Redox mechanisms involving sulfhydryls are likely because N-acetyl… CONTINUE READING
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