Quinone reductase 2 and antidepressant effect of melatonin derivatives

  title={Quinone reductase 2 and antidepressant effect of melatonin derivatives},
  author={G. Oxenkrug and S. Bachurin and Irina V Prakhie and N. Zefirov},
  journal={Annals of the New York Academy of Sciences},
  • G. Oxenkrug, S. Bachurin, +1 author N. Zefirov
  • Published 2010
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • Melatonin and its immediate precursor, N‐acetylserotonin (NAS), exert antidepressant effects in experimental models and clinical studies. We reported that melatonin and NAS decreased immobility time (an indicator of antidepressant activity) in the mouse tail suspension test. Melatonin type 3 receptor (MT3) was identified as the same protein as quinone reductase 2 (QR2) detoxifying and antioxidant enzyme. To further elucidate the role of QR2/MT3 in antidepressant action of NAS and melatonin, we… CONTINUE READING
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