Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's disease.

@article{Raina1999QuinoneR,
  title={Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's disease.},
  author={Arun K. Raina and Dennis J. Templeton and Joseph C. Deak and George Perry and Mark A. Smith},
  journal={Redox report : communications in free radical research},
  year={1999},
  volume={4 1-2},
  pages={23-7}
}
NAD(P)H:quinone oxidoreductase 1 (NQO1), a redox-regulated flavoenzyme, plays a central role in monitoring cellular redox state. NQO1 acts to protect against oxidative stress induced by a variety of metabolic situations, including metabolism of quinones and other xenobiotics, by: (i) functioning as a two electron donor to provide a shunt that competes with the formation of reactive oxygen species; (ii) maintaining reduced coenzyme Q; and (iii) regulating the stress activated kinase pathway. In… CONTINUE READING