Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity.

@article{Iskander2005QuinoneOI,
  title={Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity.},
  author={Karim Iskander and Anil K. Jaiswal},
  journal={Chemico-biological interactions},
  year={2005},
  volume={153-154},
  pages={147-57}
}
Quinone oxidoreductases (NQO1 and NQO2) are cytosolic proteins that catalyze metabolic reduction of quinones and its derivatives to protect cells against redox cycling and oxidative stress. In humans, a high percentage of individuals with myeloid and other types of leukemia are homo- and heterozygous for a null mutant allele of NQO1. The NQO2 locus is also highly polymorphic in humans. Recently, we generated NQO1-/- and NQO2-/- mice deficient in NQO1 and NQO2 protein and activity, respectively… CONTINUE READING

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