Quinolone-resistant Salmonella typhi in Viet Nam: molecular basis of resistance and clinical response to treatment.

@article{Wain1997QuinoloneresistantST,
  title={Quinolone-resistant Salmonella typhi in Viet Nam: molecular basis of resistance and clinical response to treatment.},
  author={John R. Wain and Nguyen Thi Thanh Hoa and N T Chinh and Ho{\`a}ng Văn Vinh and Martin Everett and To Song Diep and N. P. Day and Tom Solomon and Nicholas J. White and Ljv Piddock and Christopher Mark Parry},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={1997},
  volume={25 6},
  pages={
          1404-10
        }
}
  • J. Wain, N. T. Hoa, +8 authors C. Parry
  • Published 1 December 1997
  • Medicine, Biology
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Nalidixic acid-resistant Salmonella typhi (NARST) was first isolated in Viet Nam in 1993. Analysis of the quinolone resistance-determining region of gyrA in 20 NARST isolates by polymerase chain reaction and single-stranded conformational polymorphism yielded two novel patterns: pattern II corresponding to a point mutation at nucleotide 87 Asp-->Gly (n = 17), and pattern III corresponding to a point mutation at nucleotide 83 Ser-->Phe (n = 3). In trials of short-course ofloxacin therapy for… 
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Specific gyrA Mutation at Codon 83 in Nalidixic Acid-Resistant Salmonella enterica Serovar Typhi Strains Isolated from Vietnamese Patients
TLDR
All 15 strains were susceptible to a fluoroquinolone, ciprofloxacin (CIP), although three were highly resistant to NAL, and the mutation at Ser-83 to Tyr is the first report in S. enterica serovar Typhi Ty2.
Characterization of non-classical quinolone resistance in Salmonella enterica serovar Typhi: Report of a novel mutation in gyrB gene and diagnostic challenges
Characterization of Multidrug-Resistant Typhoid Outbreaks in Kenya
TLDR
Analysis of genomic DNA from both antimicrobial agent-sensitive and multidrug-resistant serovar Typhi by PFGE identified two distinct subtypes that were in circulation in the three different parts of Kenya.
The treatment of multidrug-resistant and nalidixic acid-resistant typhoid fever in Viet Nam.
  • C. Parry
  • Medicine, Biology
    Transactions of the Royal Society of Tropical Medicine and Hygiene
  • 2004
Clonal reconquest of antibiotic-susceptible Salmonella enterica serotype Typhi in Son La Province, Vietnam.
TLDR
It is shown that the Typhi isolates from Son La province in 2002 were genetically related; however, they were unrelated to the previous MDR clones established in Vietnam.
The acquisition of full fluoroquinolone resistance in Salmonella Typhi by accumulation of point mutations in the topoisomerase targets.
TLDR
The results predict that the use of ofloxac in or ciprofloxacin will select for resistance to gatifloxACin in nature.
The emergence of multidrug resistance to antimicrobial agents for the treatment of typhoid fever.
  • J. Wain, C. Kidgell
  • Biology, Medicine
    Transactions of the Royal Society of Tropical Medicine and Hygiene
  • 2004
Antimicrobial Drug Resistance of Salmonella enterica Serovar Typhi in Asia and Molecular Mechanism of Reduced Susceptibility to the Fluoroquinolones
TLDR
The pattern and extent of drug resistance in 1,774 strains of Salmonella enterica serovar Typhi isolated across Asia between 1993 and 2005 is described and the molecular mechanisms underlying the reduced susceptibilities to fluoroquinolones of these strains are characterized.
Reduced susceptibility to ciprofloxacin and gyra gene mutation in North Indian strains of Salmonella enterica serotype Typhi and serotype Paratyphi A.
TLDR
The present study carried out molecular characterization of reduced quinolone susceptibility amongst the strains of S. Typhi and S. Paratyphi A, finding that the gyrA gene mutation is sufficient to confer resistance to nalidixic acid and reduced susceptibility to ciprofloxacin.
Detection of mutation at Serine-83inQRDR of gyrA gene of drug- resistant Salmonella enterica serovarTyphiisolates from Kelantan, Malaysia using PCR-RFLP and DNA sequencing
TLDR
A total of 30 drug-resistant (DR) isolates from Kelantan, Malaysia were examined for the presence of Serine-83 to P henylalanine or Tyrosine (Tyr)substitution in the quinolone resistance-deter mining region (QRDR) of gyrA gene by polymerase chain reaction-restriction fragment (PCR-RFLP).
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