Quinolone inhibition of cytochrome P-450-dependent caffeine metabolism in human liver microsomes.

@article{Fuhr1990QuinoloneIO,
  title={Quinolone inhibition of cytochrome P-450-dependent caffeine metabolism in human liver microsomes.},
  author={Uwe Fuhr and Thomas J Wolff and S. Harder and P Schymanski and Alfred H. Staib},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1990},
  volume={18 6},
  pages={1005-10}
}
Inhibitory effects of the quinolone antibiotics ofloxacin, lomefloxacin, pipemidic acid, ciprofloxacin, and enoxacin on caffeine metabolism were examined in vitro with human liver microsomes of four donors. All drugs competitively inhibited the activity of 3-demethylation, the major pathway of caffeine metabolism. Enoxacin, ciprofloxacin, and pipemidic acid… CONTINUE READING