Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes.

@article{Tavares2002QuinolinicAS,
  title={Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes.},
  author={Rejane Giacomelli Tavares and Carla In{\^e}s Tasca and Candice E S Santos and Let{\'i}cia Biscaino Alves and Lisiane de Oliveira Porci{\'u}ncula and Tatiana Emanuelli and Diogo Onofre Souza},
  journal={Neurochemistry international},
  year={2002},
  volume={40 7},
  pages={621-7}
}
Quinolinic acid (QA) is an endogenous neurotoxin involved in various neurological diseases, whose action seems to be exerted via glutamatergic receptors. However, the exact mechanism responsible for the neurotoxicity of QA is far from being understood. We have previously reported that QA inhibits vesicular glutamate uptake. In this work, investigating the effects of QA on the glutamatergic system from rat brain, we have demonstrated that QA (from 0.1 to 10mM) had no effect on synaptosomal L-[3H… CONTINUE READING