Quinolinic acid is a potent lipid peroxidant in rat brain homogenates

  title={Quinolinic acid is a potent lipid peroxidant in rat brain homogenates},
  author={C. R{\'i}os and A. Santamarı́a},
  journal={Neurochemical Research},
  • C. Ríos, A. Santamarı́a
  • Published 2004
  • Biology, Medicine
  • Neurochemical Research
  • In this study, we describe the lipoperoxidative effect of quinolinic acid (QUIN) in vitro. The formation of thiobarbituric acid reactive products (TBA-RP), an index of lipid peroxidation, was measured in rat brain homogenates after incubation at 37°C for 30 min in the presence of QUIN and some structurally and metabolically related compounds such as Kynurenine, Kynurenic acid, Glutamate, Aspartate and Kainate. Concentrations of QUIN in the range of 20 to 80 μM increased lipid peroxidation in a… CONTINUE READING
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