Quinolinic acid in the pathogenesis of Alzheimer's disease.

  title={Quinolinic acid in the pathogenesis of Alzheimer's disease.},
  author={Gilles J Guillemin and Kieran R Williams and Danielle G. Smith and George A. Smythe and Juliana Croitoru-Lamoury and B J Brew},
  journal={Advances in experimental medicine and biology},
We propose that the tryptophan catabolites produced through the kynurenine pathway (KP), and more particularly quinolinic acid (QUIN), may play an important role in the pathogenesis of Alzheimer's disease (AD). In this study, we demonstrated that after 72 hours amyloid peptide (Abeta) 1-42 induced indoleamine 2,3-dioxygenase (IDO) expression and in a significant increase in production of QUIN by human macrophages and microglia. In contrast, Abeta11-40 and Prion peptide (PrP) 106-126 did not… CONTINUE READING


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