Quinolines as potent 5-lipoxygenase inhibitors: synthesis and biological profile of L-746,530.

@article{Dub1998QuinolinesAP,
  title={Quinolines as potent 5-lipoxygenase inhibitors: synthesis and biological profile of L-746,530.},
  author={Daniel Dub{\'e} and Marc Blouin and Christine Brideau and Chi Chung Chan and Sylvie Desmarais and Diane Ethier and J. P. Falgueyret and Richard W. Friesen and Mario Girard and Yves Girard and Jocelyne Guay and Denis Riendeau and Philip C. Tagari and Robert N Young},
  journal={Bioorganic & medicinal chemistry letters},
  year={1998},
  volume={8 10},
  pages={1255-60}
}
Leukotriene biosynthesis inhibitors have potential as new therapeutic agents for asthma and inflammatory diseases. A series of novel substituted 2-cyanoquinolines have been synthesized and the structure activity relationships were evaluated with respect to their ability to inhibit the formation of leukotrienes via the 5-lipoxygenase enzyme. [1S,5R]-2-Cyano-4-(3-furyl)-7-¿3-fluoro-5-[3-(3 alpha-hydroxy-6,8-dioxabicyclo[3.2.1]-octanyl)]phenoxymethyl ¿quinoline (L-746,530) 3 represents a distinct… CONTINUE READING
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