Quinoline anti-malarial drugs inhibit spontaneous formation of beta-haematin (malaria pigment).

@article{Egan1994QuinolineAD,
  title={Quinoline anti-malarial drugs inhibit spontaneous formation of beta-haematin (malaria pigment).},
  author={Timothy J Egan and Doug C Ross and Paul A. Adams},
  journal={FEBS letters},
  year={1994},
  volume={352 1},
  pages={54-7}
}
Polymerisation of haematin to beta-haematin (haemozoin or malaria pigment) in acidic acetate solutions was studied using infrared spectroscopy. The reaction was found to occur spontaneously between 6 and 65 degrees C, in 0.1-4.5 M acetate and pH 4.2-5.0. The anti-malarial drugs quinine, chloroquine and amodiaquin were found to block spontaneous beta-haematin formation, while the anti-malarially inactive 9-epiquinine and 8-hydroxyquinoline had no effect on the reaction, as did primaquine, a drug… CONTINUE READING
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