Quinoline alkaloids and other constituents of Melicope semecarpifolia with antiplatelet aggregation activity.

@article{Chen2001QuinolineAA,
  title={Quinoline alkaloids and other constituents of Melicope semecarpifolia with antiplatelet aggregation activity.},
  author={I S Chen and Hansen F. Chen and Ming-jen Cheng and Ya L Chang and C. M. Teng and I Tsutomu and Jih-Jung Chen and I L Tsai},
  journal={Journal of natural products},
  year={2001},
  volume={64 9},
  pages={1143-7}
}
Three new quinoline alkaloids, 2-acetylevolitrine (1), 2-acetylpteleine (2), and semecarpifoline (3), along with 26 known compounds were isolated from the root bark of Melicope semecarpifolia. The structures of 1-3 were elucidated by means of spectral analysis. In addition, (2S)-(--)-7,8-dimethoxyplatydesmine (4), cis-(+)-7,8-dimethoxymyrtopsine (5), and (3R)-(--)-8,9-dimethoxygeibalansine (6) were isolated as new natural products. Several of these isolates were determined as exhibiting… CONTINUE READING