Quinolinate-like neurotoxicity produced by aminooxyacetic acid in rat striatum


The endogenous tryptophan metabolite quinolinic acid elicits in rodent brain a pattern of neuronal degeneration which resembles that caused by L-glutamate. Its qualities as a neurotoxic agent raised the hypothesis that quinolinic acid might be involved in the pathogenesis of human neurodegenerative disorders. Kynurenic acid, another endogenous tryptophan… (More)
DOI: 10.1007/BF00805946


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