Quinolinate-induced cortical cholinergic damage: modulation by tryptophan metabolites.

  title={Quinolinate-induced cortical cholinergic damage: modulation by tryptophan metabolites.},
  author={Khem H. Jhamandas and Roland J. Boegman and R. J. Beninger and M A Bialik},
  journal={Brain research},
  volume={529 1-2},
Certain products of tryptophan metabolism interact with excitatory amino acid receptors to produce or protect against excitotoxicity. In this study, the action of several tryptophan metabolites, yielded by the kynurenine pathway, on cortical cholinergic toxicity was evaluated following focal injection into the rat nucleus basalis magnocellularis (nbM). Metabolites were injected singly or in combination with a fixed dose of quinolinic acid (QUIN). Cholinergic toxicity, or protection against it… CONTINUE READING


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Picolinic acid protects against quinolinic acid-induced cortical cholinergic damage

  • K. Jhamandas, R. J. Boegman, R. J. Beninger, M. Bialik
  • Soc. Neurosci. Abstr.,
  • 1988

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